Clinical Trial - Activ Daily

Not Just Backed by Science—Proven by It.

Others talk science—we invested in it. Activ Daily is backed by a two-year clinical trial, proving what no one else dares to test.

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Proven by science, not just backed by it.
Not just claims. Clinical proof.
Tested. Proven. Trusted.
Proven by science, not just backed by it.
Not just claims. Clinical proof.
Tested. Proven. Trusted.
Proven by science, not just backed by it.
Not just claims. Clinical proof.
Tested. Proven. Trusted.
Activ Daily

Our goal is simple: to fix every dog with gut issues in Australia—and stop those issues from coming back.

At Activ Dog Health, we don’t play the same game as everyone else. The dog supplement market is mostly unregulated, and that’s why so many companies get away with nonsense. You’ll see claims like “clinically tested ingredient” everywhere or science backed— but it means nothing. An ingredient tested in isolation has zero credibility if the final product doesn’t contain the right amount at the right dose. That’s where nearly every other company falls apart.

We went the opposite direction.

We clinically tested Activ Daily itself — at the correct dose, with the correct quantities, in the exact form your dog eats. Not a single ingredient. Not a strain. The entire Tri-Biotics formula. And we tested it twice, through two full university-run clinical trials with the University of Adelaide. No other company has gone to these lengths. Not even close.

This is why Activ Daily works.

It’s why our results are consistent.

And it’s why 86% of our customers stay with us.

Most meal toppers and probiotic powders are cheap human strains sprinkled in at token amounts — all marketing, no impact. We built something different. Species-specific prebiotics, probiotics, and postbiotics, combined with our own Microbiome Assist™ sub-strains, delivered in a stable treat that hits the gut intact.

And the proof is in the outcome. We receive hundreds of emails from owners thanking us for fixing their dog’s gut, skin, behaviour, and overall health.

While others make claims, we bring evidence.

Activ Daily isn’t another supplement.

The benchmark is Tri-Biotics.

Clinically proven. Twice.

And no one else in the industry can say that.

Activ Daily is expertly formulated to enhance your dog’s digestive process, ensuring they get the most out of every meal. No matter how nutritious your dog's diet may be, without a balanced microbiome, true health remains out of reach. Activ Daily addresses this gap, promoting optimal gut health.

By stabilizing the gut environment, Activ Daily helps reduce the occurrence of diarrhea, making each day more comfortable and carefree for your dog.

Say goodbye to uncomfortable rashes and itchy skin. Our formula supports a healthy immune system, leading to clearer, healthier skin.

A balanced gut is crucial for overall well-being, including mental health. Activ Daily aids in managing anxiety, promoting a calmer, more relaxed demeanour.

Enhanced with immune-boosting properties, Activ Daily helps your dog resist and recover from infections more effectively.

Antibiotics can disrupt your dog's natural gut flora. Our postbiotics help restore balance, ensuring a smooth recovery and robust health.

By maintaining a healthy microbial balance, Activ Daily significantly reduces the risk of yeast infections, keeping your dog comfortable and itch-free.

No more incessant paw licking or scratching. With improved overall health, these behaviours often linked to discomfort or allergies become a thing of the past.

Make the smart choice for your dog's long-term health and well-being. Choose Activ Daily – because they deserve more than just good nutrition; they deserve a foundation for a lifetime of health.

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We’re on a Mission to Fix Every Dog in Australia

At Activ Dog Health, our goal is to fix every dog in Australia with gut issues—and stop those problems from coming back. Activ Daily isn’t a quick fix. It’s a proven, long-term solution that restores and protects gut health, so your dog can thrive for life.

The Power of Prevention

Activ Daily isn’t just for fixing problems—it’s for stopping them before they begin. With our powerful triple-action formula of Prebiotics, Probiotics, and Postbiotics, you’re not just supporting your dog’s health today—you’re protecting it for the long term. It’s not just about treating symptoms; it’s about building resilience from the inside out.

Prevent the problems before they even start.

10 reasons for using "Activ Daily" Tri-biotics

Discover the top 10 reasons why "Activ Daily" Tri-biotics is a must for your dog’s health and well-being. From enhancing digestion to boosting immunity, "Activ Daily" offers a revolutionary approach to maintaining a balanced gut microbiome, tackling issues from the inside out. Designed for everyday use, our
Tri-biotics are scientifically formulated to address the root causes of common health concerns, promoting overall vitality and a happier, healthier life for your dog.

Dog Postbiotics can help alleviate digestive issues due to stress or illness

When your pet is sick or feeling stressed (for example, when she’s boarded at a kennel or is moved to a new home), the balance between healthy and illness-causing microbes in her gut can become disrupted. This can lead to issues like diarrhea, gas, cramping, and bad breath. Probiotics have been shown to reduce the duration of diarrhea in dogs from seven to four days.

Dog Probiotics decrease the side effects of antibiotics

Antibiotics do not discriminate between good and bad bacteria. And while antibiotics are effective at fighting infection, they may also cause diarrhoea or other gastrointestinal side effects in your dog. If you know ahead of time that your loyal companion will be taking antibiotics, you may be able to ward off unpleasant side effects by starting your dog on probiotics a few days in advance and continuing them beyond the duration of antibiotic treatment.

Pets with chronic gastrointestinal distress will thank you

If you have a pet that suffers from chronic intestinal distress, try giving her a high-quality dog probiotic with prebiotics daily to help replenish her gut with healthy bacteria. This practice can support a healthy inflammatory response in her GI tract and ultimately help her feel better.

Healthy gut bacteria may positively impact behaviour

One of the first signs your pet isn’t feeling well is a behavioural change. As humans do, dogs with unhealthy gut bacteria and digestion problems may also experience emotional issues. These might include behaviours like excessive licking or other obsessive-compulsive actions. So, in the process of supporting digestive health, probiotics might also improve your dog’s behaviour.

Senior dogs need extra TLC to keep them healthy and feeling good

Older dogs are much more susceptible to weakened immune systems. And since almost 70 percent of immune cells are in the gut, promoting the growth of healthy, or ‘good,’ bacteria in the GI tract is a sound way to help boost immunity. Your dog’s gut flora is very important to her overall health and well-being and may be the key to living a long, happy life.

Dog probiotics can help prevent issues related to unhealthy bacterial balance

Constipation is no fun, for humans and dogs alike. Painful gas, bloating and cramping can, if left untreated, also lead to vomiting, lethargy, and loss of appetite. Together, exercise, fresh water, and dog probiotics support a healthy gut environment, so that your pet doesn’t have to suffer from painful issues related to unhealthy gut bacteria.

Dog probiotics can help minimize tummy upset due to a change in food

If your dog has been eating the same food for a long time and you make a switch, I can almost guarantee your furry friend will experience gastrointestinal distress as a result. Prep your dog’s gut with probiotics to level the playing field against the ‘good’ and ‘bad’ bacteria before changing to a different food.

Dog probiotics can help reduce skin allergy symptoms

Allergies (which are essentially misguided immune system responses) are on the rise in humans and dogs alike. Researchers have attributed this, in part, to an imbalance of bacteria in the gut. Because gut and immune health are so intertwined, giving your dog probiotics may lessen skin allergy symptoms. Several studies support this theory, having demonstrated that dog probiotics may be effective for allergy management.

Who doesn’t want healthier teeth?

Preliminary research suggests that giving your dog probiotics could also support her dental health. That’s reason for both of you to smile!

A healthier gut can mean better skin, coat, and breath

Promoting the growth of healthy gut bacteria can have all sorts of beneficial effects on the body, making you look and feel better. When you give your pup a daily dog probiotic you’ll likely see the benefits on the outside of her body, as she begins to feel better on the inside. 

Clinically Proven Results: Two University of Adelaide Trials Show Activ Daily Transforms the Gut–Skin Microbiome

For years, the pet supplement market has been full of bold claims—but very little real science. Activ Dog Health set out to change that.

To prove Activ Daily works, we conducted two full clinical trials with the University of Adelaide over a 3 year period, using the most advanced microbiome technology available. No other pet supplement company has gone to these lengths.

The results are now published in peer-reviewed scientific journals—and they confirm what dog owners have been seeing for years.

Trial 1: Skin Microbiome Clinical Study (Veterinary Dermatology, 2025)

Researchers studied twelve Golden Retrievers living in the same controlled environment for 90 days to eliminate outside variables. Each dog received a daily Activ Daily chew containing our four species-specific ADH™ strains.

Full-length PacBio HiFi sequencing—the gold standard in microbiome science—identified over 3,800 bacterial species, offering the most detailed picture of the canine skin microbiome ever produced.

Key findings after 90 days:
  • 7× increase in Lactobacillus acidophilus (ADH™-302)
  • 37× increase in Dubosiella newyorkensis
  • 40× increase in Roseomonas vastitus

These beneficial species are linked with:

  • stronger skin barrier function
  • improved immune regulation
  • reduced inflammation

Culture-based testing also showed a significant reduction (p = 0.02) in Staphylococcus pseudintermedius—a major cause of itching, redness and canine skin infections.

The study confirmed a clear shift toward a healthier, more diverse, more resilient skin microbiome, demonstrating that daily oral supplementation can improve skin health from the inside out.

Trial 2: Gut–Skin Axis Clinical Study (Veterinary Research Communications, 2025)

The second study analysed how Activ Daily shapes both the gut microbiome and skin microbiome simultaneously—a world-first in dogs.

Using the same dogs, researchers tracked the microbiome at Day 0, Day 30 and Day 90. Advanced long-read sequencing again provided species-level accuracy.

Key findings:
  • Significant shifts in gut microbiota composition (PERMANOVA p = 0.05)
  • Large increases in three core beneficial species:
    Lactobacillus acidophilus
    Lactobacillus johnsonii
    Limosilactobacillus reuteri

  • These same bacteria increased on the skin, showing a direct gut–skin connection
  • Positive correlations between gut and skin bacteria confirmed that Activ Daily improves health systemically, not just locally

Importantly, Lactobacillus acidophilus showed exceptional ability to survive, colonise and establish in both gut and skin—proving the strength of our proprietary ADH™ strains.

What This Means for Your Dog

Together, these two trials show that Activ Daily:

  • Restores balance in the gut
  • Improves skin microbiome health
  • Reduces harmful bacteria linked to infections and itching
  • Increases microbial diversity, a key marker of long-term health
  • Strengthens the gut–skin axis, improving health from the inside out

And unlike supplements built on generic “clinically tested ingredient,” these trials tested the entire formula at the correct daily dose—the only testing that actually matters.

This is also why Activ Daily has an 86% customer retention rate and hundreds of testimonials from owners who have seen their dog’s skin, digestion and behaviour dramatically improve.

The Most Scientifically Validated Canine Tri-Biotic Supplement Available

Activ Daily is the only dog supplement backed by:

  • Two independent clinical trials
  • University-led research teams
  • Full-length 16S rRNA sequencing
  • Species-specific ADH™ strains developed for dogs—not humans

No shortcuts. No borrowed ingredient studies. No vague claims.

Just real science, proven in peer-reviewed journals.